Worry About Getting Too Fat No More? Researchers from the Washington University School of Medicine in St. Louis have successfully disabled a gene in specific mouse cells, preventing mice from becoming obese even after being fed a high-fat diet. Macrophages, vital inflammatory cells which are responsible for detecting, engulfing and destroying pathogens, were blocked by … Read more
CRISPR corrects genetic defect so cells can normalize blood sugar Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had … Read more
New research suggests that transient receptor channels (TRPs) activated in progenitor cells can help create more According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) (“good” fat) by employing two receptors on BAT cells as potential therapeutic targets. Both receptors, … Read more
The Gene: An Intimate History weaves together science, history & personal stories for a historical biography of the human genome, while also exploring breakthroughs for diagnosis & treatment of genetic diseases & the complex ethical questions they raise. ABOUT THE SERIES “The Gene: An Intimate History” is a major new four-hour documentary from Ken Burns … Read more
Researchers used a modified CRISPR gene editing technique to target the fat cells of obese, diabetic mice. After 6 weeks, the animals had lost weight, and markers of type 2 diabetes had improved. According to the World Health Organization (WHO), in 2016, more than 1.9 billion adults worldwide were overweight, over 650 million of whom … Read more
CRISPR gene editing. It’s gone from an obscure biotech term to a household name in the past few years, in no small part due to a scientist who last year announced that he’d not only modified the DNA of human embryos but that two baby girls had been born carrying the edits he’d made. The … Read more
Gene therapies have been a point of discussion during the last several years as a potential curative option for a variety of disease indications. The majority of the cardiovascular and metabolic disorder (CVMD) gene therapies in development are targeting cardiovascular indications, indicating immense opportunity for biotech companies to pursue drug candidates that target metabolic disorders, … Read more
DelveInsight’s Metabolic disorders based Gene Therapy Reports Metabolic disorders are collectively common, frequently severe and in many instances difficult or impossible to treat. Accordingly, there is a compelling need to explore novel therapeutic modalities, including gene therapy, and examine multiple phenotypes where the risks of experimental therapy are outweighed by potential benefits to trial participants. … Read more