Aracea Therapeutics

Brown, white, and beige: Understanding your body’s different fat cells could help with weight loss

We know that carrying excess fat is bad for us and can contribute to a number of diseases, such as diabetes. But not all fat is created equal.

While certain types of fat cells can accumulate in our bodies and cause health problems, other types have evolved to turn fuel into heat – so they can actually burn calories. Recent research even shows that having higher concentrations of “good” fat cells [brown fat] in our bodies can help us burn more calories, especially when we’re exposed to cold temperatures.

This idea of different “colored” fats – brown, white, and beige – often comes up in fad diets encouraging you to eat special foods for weight loss without much proof they work. But understanding the science behind these different types of fat cells really could be an important way to keep healthy, and even treat serious conditions such as obesity.

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BAT contributes to energy expenditure. Weight gain and obesity are caused by chronic periods of positive energy balance. Energy intake comes from food consumption, whereas the major contributors to expenditure are exercise and basic metabolic processes. The studies reviewed here suggest that BAT activity could impact daily energy expenditure. BAT dissipates energy as heat and can thus counteract weight gain. Inter-individual variability in the amount or function of this tissue may impact body weight. In addition, therapeutic expansion/activation of this tissue may prove to be an effective therapy for obesity. WAT, white adipose tissue.

White, brown, and beige cells

There are two main types of fat cells. White fat cells are found in they body’s connective tissues, usually beneath the skin (subcutaneous fat) and in the abdominal cavity (visceral fat). When we eat food, the white fat cells primarily convert excess energy in the form of glucose that it doesn’t need into lipid droplets, usually as molecules called triglycerides. These produce signalling molecules that regulate appetite and energy balance.

Brown fat cells, on the other hand, were traditionally believed to be found only in newborn babies and would disappear in infancy. Later, research showed that brown fat cells exist in the body throughout your life. Brown fat cells are located in regions between the shoulder blades, neck, along the spinal cord, and above the collarbone. But they can emerge in other parts of the body such as around the vital organs, where they turn food into heat.

But research has found a third type of fat cells, called beige or “brite” (brown in white) fat cells. These cells act like brown fat cells, but are found in similar areas as white fat cells. Beige fat cells are derived from white fat in a process called “browning” which is triggered by exposure to low temperatures, typically 3°C above a person’s shivering temperature point, which is around 11°C for women and around 9°C for men.

Other stimuli such as good nutrition and exercise are also believed to encourage the browning process.

What their appearance means

White fat cells are typically round cells of variable sizes with a single, large, lipid droplet. These droplets can be converted to fatty acids during starvation or when energy demands increase. Fatty acids are the building blocks of fats which can be absorbed into the blood.

Brown fat cells are smaller, and have many small lipid droplets per cell. Brown fat cells also contain many energy generating organelles called mitochondria. These are rich in iron, which give them their brown color when exposed to oxygen.

Beige fat cells have features midway between white and brown. They come from white parent cells, but function like brown fat cells by burning energy to produce heat when the core body temperature dips. The browning process is helped by cold temperatures, and the nervous and immune systems.

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Changing fat type

It’s long been known that white fat cells can acquire the characteristics of brown fat cells under certain conditions, such as low temperatures and certain proteins. The conditions for natural change can also be sped up. Nutritional supplements, such as the flavonoids resveratrol and quercetin, which are found in fruits and vegetables, can help the browning process. Exercise has also been shown to increase browning.

Exposure to temperatures slightly above the shivering point for at least two hours is also known to help with browning. However, this needs to be practiced regularly to see any real changes.

Studies also show that brown fat cells are associated with better health. They encourage weight loss, which may subsequently reduce obesity and other related diseases caused by excess weight.

Brown fat cells also reduce the risk of hypothermia and can reduce the risk of diabetes by increasing insulin sensitivity. The ability to cause the browning of white fat cells and turn them into beige cells therefore brings the potential for better health.


Source: Trust Diya, Staffordshire University. theconversation.com/brown-white-and-beige-understanding-your-bodys-different-fat-cells-could-help-with-weight-loss-138141.